WebPolypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization.[1] Two 2024 studies have shown that depleting PTB mRNA in astrocytes can convert these astrocytes to functional … WebThe production of illegitimately transcribed mRNA from peripheral blood leukocytes and its use for mutational analysis of many tissue‐specific genes has been known for 15 years [1]. Two recent publications in this journal by Green et al. and Cutler et al. [2,3] have, however, highlighted the difficulty in using ‘illegitimate’ transcripts of factor FIX mRNA isolated …
Isolation of a Sequence-Specific RNA Binding Protein, Polypyrimidine …
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Splice factor polypyrimidine tract-binding protein 1 …
WebJul 24, 2024 · Regulation of translation Structural Changes Mediated by Poly ( rC ) Binding Protein 1 and Recruitment initiation in eukaryotes: mechanisms and biological targets. Cell 136, 731–745. of Polypyrimidine Tract Binding Protein 1.. Mol. Cell. Biol. 24, 5595–5605. WebRecently, the polypyrimidine tract-binding protein 1 (PTPBP1) splicing repressor has been implicated in the regulation of alternative splicing of FGFR1α and FGFR1β. The study conducted in breast cancer cells revealed that PTBP1 represses the splicing of FGFR1β [ … WebHere we show that genes encoding critical presynaptic proteins are transcribed at a detectable level in both neurons and nonneuronal cells. However, in nonneuronal cells, the splicing of 3′-terminal introns within these genes is repressed by the polypyrimidine tract-binding protein (Ptbp1). dutch fix