Webb2 mars 2024 · Abstract. Ferroptosis is a type of iron-dependent regulated necrosis induced by lipid peroxidation that occurs in cellular membranes. Among the various … WebbThe disease databases, including GeneCards, 40 OMIM, 41 TTD, 42 CTD 43 and FerrDb, 44 were used to screen the depression and ferroptosis-related targets. Then, each target of active ingredients, depression and ferroptosis were searched in the UniProt database 45 to get the UniProt gene ID. Here, 12,608 depression-related targets and 260 ferroptosis …
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Webb18 jan. 2024 · Ferroptosis is a type of non-apoptotic RCD, which is characterized by lipid peroxidation and plasma membrane damage [3, 4]. With the discovery of various regulators and pathways, basic research in ferroptosis is rapidly expanding, thus providing new opportunities to treat various pathological conditions and diseases [5, 6]. Webb13 apr. 2024 · The role of ferroptosis, a recently described specific pathway of regulated cell death, is presented. ... The transformation of phagophores into autophagosomes requires the Atg12–Atg5–Atg16 complex and the phosphatidylethanolamine (PE)-conjugated LC3II (Atg8) system. ... A pro-apoptotic role of autophagy has also been …
Webb5 okt. 2024 · This, in turn, decreased the pro-ferroptosis phosphatidylethanolamine (PE) (18:0/20:4) and PE (18:0/22:4) content and contributed to ferroptosis resistance. Notably, CBSLR is upregulated, whereas CBS is downregulated in GC tissues compared to matched normal tissues; and GC patients with high CBSLR /low CBS levels have a worse clinical … Webb11 mars 2024 · Phosphatidylethanolamine is a major lipid component of cellular membranes in a wide range of organisms 1, 2. In Escherichia coli, PE accounts for …
Webb23 jan. 2007 · Phosphatidylethanolamine-binding protein 1 Short names PEBP-1 Alternative names HCNPpp Neuropolypeptide h3 Prostatic-binding protein Raf kinase inhibitor protein ( RKIP) Cleaved into 1 chains Hippocampal cholinergic neurostimulating peptide ( HCNP) Gene names Name PEBP1 Synonyms PBP, PEBP Organism names … WebbThe research shows 37 that ether lipids include lecithin and phosphatidylethanolamine, mainly assuming functions of membrane transport, cell differentiation, and antioxidant activities to stabilize the cell structure and protect the internal components against degradation. 38–42 The proteins found in exosomes include tetrapeptide, …
WebbI am currently a graduate student at East Carolina University, pursuing my Master of Science Degree in Chemistry. I am a graduate teaching assistant for General Chemistry II and Organic Chemistry ...
Webb1 okt. 2024 · Ferroptosis is a type of nonapoptotic and iron-dependent regulated cell death that can propagate between cells, thereby affecting entire cell populations [1]. … the lakes on post oakWebb6 juni 2024 · Polyunsaturated fatty acid-containing phospholipids are the main substrates of lipid peroxidation in ferroptosis, which is positively regulated by enzymes, such as ACSL4, LPCAT3, ALOXs, or POR. Selective activation of autophagic degradation pathways promotes ferroptosis by increasing iron accumulation to cause lipid peroxidation. the lakes pembroke pinesWebb1 okt. 2024 · PDF Introduction Tumors are usually refractory to anti-cancer therapeutics under hypoxic conditions. However, the underlying molecular mechanism... Find, read and cite all the research you ... the lakes port st lucieWebbFerroptosis, first reported in 2012, is a newly defined form of RCD involving irondependent, non-apoptotic cell death. The characterization methods included free iron and lipid reactive oxygen species (ROS), particularly lipid hydroperoxides[5], and by cytoplasmic and organelle swelling, chromatin condensation and mitochondrial disorder[6,7]. the lakes poetsWebb11 jan. 2024 · PMID: 33432112 Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2 Xiang Luo,#1,2Hai-Biao Gong,#1,2Hua-Ying Gao,#1,2Yan-Ping Wu,1,2,3Wan-Yang Sun,1,2Zheng-Qiu Li,2Guan Wang,4,5Bo Liu,4,5Lei Liang,1,2Hiroshi Kurihara,1,2Wen-Jun Duan,1,2Yi-Fang Li,1,2and … the lake song lyricsWebb2 dec. 2024 · Ferroptosis is a regulated cell death mainly manifested by iron-dependent lipid peroxide accumulation. The leading cause of ferroptosis is the imbalance of intracellular oxidative systems (e.g., LOXs, POR, ROS) and antioxidant systems (e.g., GSH/GPx4, CoQ10/FSP1, BH4/GCH1), which is regulated by a complex network. In the … the lake spa hotelWebb24 nov. 2024 · Aguilera et al. show that ferroptosis, ... The 50°C-HS induced the accumulation of oxidized species of phosphatidylethanolamine (PE; 36:4-OO and 36:5-OO) and phosphatidylglycerol (PG; 34:2-O, 34:2-OO, ... Lipidomic studies have identified oxidized arachidonic/adrenic PEs as pro-ferrototic signals in human cells (Kagan et al., ... the lakes psychiatric hospital